Amid the AI trade and ongoing geopolitical tensions, several US-listed stocks have come under pressure in 2026. Here are the top 10 stocks with market capitalisations above $5 billion that have fallen between 49% and 66% year to date, according to Vested Finance data. The Trade Desk has emerged as the biggest loser on this list, with shares plunging 65.75% in 2026, from $37.96 at the end of last year to $13.00.